| 1 |  Pirates Of The Caribbean 2, Dead Man's Chest (2006) | Gore Verbinski |
$423.3M |
| 2 | Night At The Museum 1 (2006) | Shawn Levy |
$250.8M |
| 3 | Cars (2006) | N/A |
$244.1M |
| 4 | X 3, The Last Stand (2006) | N/A |
$234.3M |
| 5 | Da Vinci Code, The (2006) | N/A |
$217.5M |
| 6 | Superman Returns (2006) | N/A |
$200.1M |
| 7 | Happy Feet (2006) | George Miller |
$198M |
| 8 | Ice Age 2: The Meltdown (2006) | N/A |
$195.3M |
| 9 | James Bond 21, Casino Royale (2006) | Martin Campbell |
$167.4M |
| 10 |  Pursuit Of Happyness, The (2006) | Gabriele Muccino |
$164.1M |
| 11 | Over The Hedge (2006) | N/A |
$155M |
| 12 | Knocked Up (2006) | Judd Apatow |
$148.4M |
| 13 | Talladega Nights: The Ballad Of Ricky Bobby (2006) | N/A |
$148.2M |
| 14 | Click (2006) | N/A |
$137.3M |
| 15 | Mission: Impossible 3 (2006) | J.J. Abrams |
$133.4M |
| 16 | Departed, The (2006) | Martin Scorsese |
$132.4M |
| 17 | Borat (2006) | Larry Charles |
$128.5M |
| 18 | Devil Wears Prada, The (2006) | N/A |
$124.7M |
| 19 | Break Up, The (2006) | N/A |
$118.7M |
| 20 | Dreamgirls (2006) | N/A |
$103.1M |
| 21 | Scary Movie 4 (2006) | David Zucker |
$90.7M |
| 22 | Failure To Launch (2006) | Tom Dey |
$88.7M |
| 23 | Inside Man (2006) | Spike Lee |
$88.5M |
| 24 | Santa Clause 3: The Escape Clause, The (2006) | Michael Lembeck |
$84.5M |
| 25 | Open Season (2006) | Roger Allers |
$84.3M |
| 26 | Charlotte'S Web (2006) | Gary Winick |
$82.5M |
| 27 | Pink Panther, The (2006) | Shawn Levy |
$82.2M |
| 28 | Eight Below (2006) | Frank Marshall |
$81.6M |
| 29 | Nacho Libre (2006) | N/A |
$80.2M |
| 30 | Saw 3 (2006) | Darren Lynn Bousman |
$80.2M |
| 31 | You, Me And Dupree (2006) | N/A |
$75.6M |
| 32 | Eragon (2006) | Stefen Fangmeier |
$75M |
| 33 | Monster House (2006) | N/A |
$73.7M |
| 34 | Barnyard: The Original Party Animals (2006) | N/A |
$72.8M |
| 35 | Jackass 2: Number Two (2006) | Jeff Tremaine |
$72.8M |
| 36 | R.V. (2006) | N/A |
$71.4M |
| 37 | Rocky 6, Rocky Balboa (2006) | Sylvester Stallone |
$70.3M |
| 38 | World Trade Center (2006) | N/A |
$70.2M |
| 39 | Big Momma's House 2 (2006) | John Whitesell |
$70.2M |
| 40 | Step Up 1 (2006) | N/A |
$65.3M |
| 41 | Flushed Away (2006) | David Bowers |
$64.6M |
| 42 | Deja Vu (2006) | Tony Scott |
$64M |
| 43 | Miami Vice (2006) | Michael Mann |
$63.4M |
| 44 | Madea's Family Reunion (2006) | Tyler Perry |
$63.2M |
| 45 | Holiday, The (2006) | Nancy Meyers |
$63.2M |
| 46 | Fast And The Furious 3: Tokyo Drift, The (2006) | N/A |
$62.5M |
| 47 | Underworld 2: Evolution (2006) | Len Wiseman |
$62.3M |
| 48 | Shaggy Dog, The (2006) | Brian Robbins |
$61.1M |
| 49 | Poseidon (2006) | Wolfgang Petersen |
$60.7M |
| 50 | Good Shepherd, The (2006) | Robert De Niro |
$59.9M |
| 51 | Little Miss Sunshine (2006) | N/A |
$59.9M |
| 52 | Curious George (2006) | Matthew O'Callaghan |
$58.3M |
| 53 | Little Man (2006) | N/A |
$58.3M |
| 54 | Invincible (2006) | Ericson Core |
$57.8M |
| 55 | Benchwarmers, The (2006) | Dennis Dugan |
$57.7M |
| 56 | Blood Diamond, The (2006) | Edward Zwick |
$57.3M |
| 57 | Queen, The (2006) | Stephen Frears |
$56.4M |
| 58 | Guardian, The (2006) | Andrew Davis |
$55M |
| 59 | Omen, The (2006) | N/A |
$54.6M |
| 60 | Final Destination 3 (2006) | James Wong |
$54.1M |
| 61 | Prestige, The (2006) | Christopher Nolan |
$53.1M |
| 62 | Lake House, The (2006) | N/A |
$52.3M |
| 63 | Hoodwinked! The True Story of Red Riding Hood (2006) | Cory Edwards |
$51.1M |
| 64 | Apocalypto (2006) | Mel Gibson |
$50.9M |
| 65 | Firewall (2006) | Richard Loncraine |
$48.7M |
| 66 | Date Movie (2006) | Jason Friedberg |
$48.5M |
| 67 | When A Stranger Calls (2006) | Simon West |
$47.9M |
| 68 | Silent Hill (2006) | Christophe Gans |
$47M |
| 69 | We Are... Marshall (2006) | N/A |
$43.5M |
| 70 | Deep Sea 3-D (2006) | N/A |
$43.4M |
| 71 | Glory Road (2006) | James Gartner |
$42.6M |
| 72 | Lady In The Water (2006) | M. Night Shyamalan |
$42.3M |
| 73 | Hills Have Eyes, The (2006) | Alexandre Aja |
$41.8M |
| 74 | John Tucker Must Die (2006) | N/A |
$41M |
| 75 | Stranger Than Fiction (2006) | Marc Forster |
$40.1M |
| 76 | Illusionist, The (2006) | N/A |
$39.8M |
| 77 | Texas Chainsaw Massacre 2: The Beginning, The (2006) | Jonathan Liebesman |
$39.5M |
| 78 | Grudge 2, The (2006) | Takashi Shimizu |
$39.1M |
| 79 | Gridiron Gang (2006) | Phil Joanou |
$38.4M |
| 80 | Last Holiday (2006) | Wayne Wang |
$38.4M |
| 81 | Pan'S Labyrinth (2006) | Guillermo Del Toro |
$37.6M |
| 82 | Nativity Story, The (2006) | Catherine Hardwicke |
$37.5M |
| 83 | Man Of The Year (2006) | Barry Levinson |
$37.4M |
| 84 | Wild, The (2006) | Steve 'Spaz' Williams |
$37.4M |
| 85 | 16 Blocks (2006) | Richard Donner |
$36.9M |
| 86 | Accepted (2006) | N/A |
$36.3M |
| 87 | Sentinel, The (2006) | Clark Johnson |
$36.3M |
| 88 | Smokin' Aces (2006) | Joe Carnahan |
$35.6M |
| 89 | Children Of Men (2006) | Alfonso Cuaron |
$35.3M |
| 90 | Deck The Halls (2006) | John Whitesell |
$35.1M |
| 91 | Take The Lead (2006) | Liz Friedlander |
$34.7M |
| 92 | Babel (2006) | Alejandro Gonzalez Inarritu |
$34.3M |
| 93 | Snakes On A Plane (2006) | David R. Ellis |
$34M |
| 94 | She's The Man (2006) | Andy Fickman |
$33.7M |
| 95 | Flags of Our Fathers (2006) | Clint Eastwood |
$33.6M |
| 96 | United 93 (2006) | Paul Greengrass |
$31.5M |
| 97 | Employee Of The Month (2006) | Greg Coolidge |
$28.4M |
| 98 | Garfield 2, A Tail Of Two Kitties (2006) | N/A |
$28.4M |
| 99 | Ant Bully, The (2006) | N/A |
$28.1M |
| 100 | Crank (2006) | Mark Neveldine |
$27.8M |
